Alessandro Biffignandi was born in Rome in 1935. He learned the finer points of drawing at the Favalli studios. In 1960, he settled in Milan, where he started working for many important periodicals and publishers. From the late 1950s to the early 1960s, he worked through the Milanese art agencies for the French market.
He did painted covers for the pocket publications of the publishing house Lug, such as Nevada, Hondo, Kiwi, Yuma and Rodeo. He also drew some comics for the books, such as 'Flambo', 'Agent K-3', 'Peter Berg', 'John Kine' and 'Rombo Bill'. In the late 1960s, he worked for the British Fleetway agency, doing painted covers of 'The Spider'. Since the early 1980s, he is mainly an illustrator and oil painter.