After the artistic grammar school, Alessandro Bignamini attended the Comics School in Milan. He began his professional career in 1990, drawing for Fumo di China and Comic Art. He cooperated on Intrepido from 1992, where he did various short stories. Bignamini illustrated four episodes of the series 'Orazio Brown'. He joined Bonelli publishers in 1994, where he became a staff artist of 'Mister No'.