Pierre Billon began his career in comics as an editor and translator of American comics published in magazines like for Before World War II, Pierre Billon was Robinson, Hop là and Le Journal de Mickey. When World War II broke out and the American material couldn't reach the editors, he turned to the drawing board himself. Robins ran Billon's first comic story 'Le Docteur X', in 1940 and 1941. It was followed by 'Yann, Le Prince des Mers', also in 1941.
He drew 'La Famille Durondel' in Le Journal de Mickey in 1942 and 1943 and began an association with Éditions Vaillant in 1947. He produced educational sections in the tradition of 'Ripley's Believe It Or Not' for the publisher's magazine of the same name. Besides creating several comic stories for post-war magazines like Mon Journal, Billon was also present in the daily press with vertical strips like 'Mandrin' in L'Humanité (1953), 'Les Aventures du Professeur Carrier à travers l'Espace' in Libération (1958) and 'Berlioz' in L'Humanité Dimanche' (1959). He retired from comics in 1969. His son was comic artist Daniel Billon.
He should not be confused with French singer Pierre Billon (1947).