Born and raised in New York City, Frank Bolle showed an interest in drawing at an early age. His parents, who were both artists, strongly influenced him as a child. After serving in World War II, Bolle attended the Pratt Institute. His professional career in comics began in 1948, when he did western comics for Magazine Enterprises, like 'Tim Holt', 'Redmask' and 'Best of the West'. He also joined Western Publishing, where he illustrated several Golden Books, such as 'Sherlock Holmes', 'Lone Ranger' and 'Lassie and the Lost Wagon'. He did several science-fiction comics, like 'Buck Rogers', 'Flash Gordon' and 'Dr. Solar, Man of the Atom'.
At Western, he also illustrated several of 'Grimm's Ghost Stories', 'Boris Karloff's Tales of Mystery', 'Ripley's Believe it or Not' and 'Rod Sterling's Twilight Zone'. At the same time, he produced the syndicated Sunday feature 'Children's Tale'. For the daily press he also was an assistant on Leonard Starr's 'On Stage' (1956-1961) and he illustrated 'Debbie Deere', 'Alexander Gate', 'Rip Kirby' and 'Encyclopedia Brown' in the 1960s and 1970s.
Bolle drew Stan Drake's 'The Heart of Juliet Jones' for King Features Syndicate from 1984 to 1999, as well as 'Winnie Winkle', originally created by Martin Branner, for twenty years. At the same time, he did the daily 'Little Orphan Annie' strip, originally created by Harold Gray. In the late 1990s, he took on Alex Kotzky's 'Apartment 3-G' daily, and additionally did contributions to the 'Gil Thorp' strip.