Les Carroll attended the Landon School and began his career working as a background artist for the Fleischer animation studios in the 1930s. He also worked on cartoon productions by Schlessinger and Pat Sullivan. He did comic book art in the 1940s and eventually became a staff artist at N.E.A. Between 1945 and 1960 he produced the syndicated comic strip 'The Tillers'.
He was the assistant of Abe Martin and took over the 'Boots and her Buddies' Sunday page after Martin's death in 1960. The strip, accompanied by its topper 'Babe 'n' Horace', ran until March 1969. Carroll has also assisted V.T. Hamlin on 'Alley Oop' in the 1960s.