Born in Puerto Rico and raised in the USA, Ernie Colon began his professional career in the late 1960s. Colon worked for publishing house Harvey for twenty years, initially as a lettere, but later as an artist on series like 'Casper the Friendly Ghost', 'Monster in My Pocket' and 'Richie Rich'. His work was also featured in the Warren horror magazines Creepy, Vampirella and Eerie.
He has worked extensively with Sid Jacobsen, starting with the 'Black Comic Book' in 1970. After the folding of Harvey, Colon became a freelancer for other companies. He has worked on titles like 'Grim Ghost' for Atlas/Seaboard, 'Arak, Son of Thunder' and 'Amethyst, Princess of Gemworld' for DC Comics, 'Airboy' for Eclipse Comics, 'Magnus: Robot Fighter' for Valiant Comics, and 'Damage Control' and 'Doom 2099' for Marvel Comics.In recent years he was involved in online and digital comics, like 'Doodle' movies for the Komikwerks company.
Colón is the author of the science-fiction graphic novel 'Ax' and since 2005, he does the weekly comic 'SpyCat' in the Weekly World News'. With Sid Jacobsen, he has done two books on the 9/11 terrorist attacks, called 'The 9/11 Report: A Graphic Adaptation' (2006) and 'After 9/11: America's War on Terror' (2008). They then made the comic biographies of 'A Graphic Biography: Che' (2009) and 'A Graphic Biography: Anne Frank' (2010).