Didier Comès was born in the small Belgian town of Sourbrodt, near the German border. Since the town was occupied by the Germans during his birth, Comès was initially called Dieter Hermann Comès. After the Liberation, his name was changed to Didier. He took art courses in Malmédy, after which he began as an apprentice industrial designer at a textile factory in Verviers, where he worked from 1959 to 1969. In his spare time, he began to draw comics. He took his comic activities to a more professional level after meeting René Hausman and Paul Deliège. Comès's first professional comics were published in the children's supplement of Le Soir and included strips like 'Hermann', 'Sventebold' and 'Les Cheeses'.
After a brief stint in Spirou, Didier Comès started his first big series in Pilote, called 'Ergün l'Errant', in 1973. The series was soon cancelled, but was revived in À Suivre under the name 'Le Maître des Ténèbres' in 1980. The series was continiued by Patrick Deubelbeiss and Benoît Peeters from 1987. In 1976 and 1977, Comès created the Pratt-inspired 'L'Ombre du Corbeau', a dark surrealistic tale about World War I in the Belgian edition of Tintin.
In 1980s, he established himself as a master of so-called comic novels, such as 'Silence', 'La Belette' and 'Iris', that often deal with themes like witchcraft and mythology. He continued his work for À Suivre with 'Eva', 'L'Arbre-Coeur' and 'La Maison où Rêvent les Arbres'. Since 2000, Casterman has published his graphic novels 'Les Larmes du Tigre' (2000) and 'Dix de der' (2006). Didier Comès passed away in March 2013, at the age of 70.