Carine de Brab decided to become a comics artist for cildren early on. She studied at the Saint-Luc in Brussels, while she also cooperated on the animated feature film 'Le Chaînon Manquant' by Picha. After some advertising jobs, she met Yvan Delporte, with whom she did her first comics work. They cooperated on some 'Les Zingari' scripts (art by René Follet), before they created 'Les Puzoletti' in Spirou in 1987, which featured De Brab's artwork. She continued to work for Spirou magazine in the following years, creating short stories, game pages and the gag series 'Suzy' (with Salma).
For l'Écureuil, she made the gag series 'Tamia et Piko'. In 1992 she started the series 'Margot et Oscar Pluche' with writers Zidrou and Falzar at Casterman. This series was continued in Spirou and in albums by Dupuis under the name 'Sac à Puces' from 1998. In addition, she made 'Choco' in cooperation with Zidrou at Casterman in 2000.
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