Arturo Pérez Del Castillo was born in Concepcion, Chile. He started working for an advertising agency, but eventually joined his brother Jorge Perez del Castillo in Buenos Aires, Argentina, in 1948. He got a job as a letterer on the comic weekly Aventuras. A year later, Del Castillo collaborated with the magazines Intervalo and El Tony with a series of comic strips. He quickly became famous for his skillful and detailed penwork.
In the late 1950s, Del Castillo drew a number of comic strip adaptations of Alexandre Dumas' novels, such as 'The Three Musketeers' and 'The Man in the Iron Mask', which were published in British magazines. Also for Britian, he drew western stories in Top Spot ('Ringo') and Ranger ('Dan Dakota - Lone Gun') and for the Cowboy Picture Library.
His most famous creation, however, was the Hector Oesterheld scripted 'Randall: the Killer' series, which commenced publication in Hora Cero in 1957. Del Castillo refined his graphic style even further and other important works followed. He produced 'Garret' with scriptwriter Ray Collins (Eugenio Zappietro) in Misterix in 1962. The series restarted as 'El Cobra' in Skorpio from 1974. Del Castillo did a comic about vikings with Alfredo Grassi in Tit-Bits and created 'Loco Sexton' with Oesterheld in Skorpio. In the mid-1970s, he also produced 'Ralph Kendall' and 'Ralph O'Connor' for the Italian market through the Roy d'Ami studios. He worked for the publishing house Record until his retirement in 1989. Arturo Del Castillo died in Buenos Aires in 1992.