Originally from Argentina, José Delbo has drawn for American comic books since the 1960s. He drew stories with 'Secret Agent Mike Manley' for 'Fight the Enemy', a comic book that appeared on Wally Wood's and Samm Schwartz' Tower Comics line in the 1960s. He also contributed to Judge Colt with writer Dorfman. Delbo started drawing for DC in the 1970s. He worked on the 'Superman' spin-offs 'Supergirl', 'Jimmy Olsen' and 'Lois Lane', as well as several 'Wonder Woman' issues. He also drew the 'Superman' daily strip for a while. He was also present at Gold Key, drawing for titles like 'Buck Rogers' and 'Doctor Solar'.
Delbo drew for several Marvel titles based on popular television cartoon in the 1980s and 1990s. In the mid-1980s, he pencilled some issues of 'Thundercats'. He was the regular penciller on 'The Transformers' from 1988 to 1990, and he drew the first two issues of 'Captain Planet and the Planeteers' in 1991. He then went on to do 'Brute Force' in 1990 and 'NFL Superpro' in 1991-92. In the 1990s, he also drew for 'Mickey Spillane's Mike Danger' at Tekno and Big.