Miesjel van Gerwen was born in Heeze, The Netherlands, in 1950. He studied at the Academie voor Kunst & Vormgeving in 's Hertogenbosch. Since then, he has been active as a graphic designer, illustrator, comic artist and theater designer. He was the main artist for Vuistje, an independent comics magazine for children, of which 11 issues were published by Sjaloom in Odijk in 1975-76.
Miesjel van Gerwen has contributed comics, among others, to magazine Vox, and he was founder, editor and contributor of youth magazine Zone 3, which ran from 1983 until 1985. For De Zelfkrant, the homeless paper of Den Bosch, he has created the comic strip 'Straathonden'. For local newspaper Brabants Dagblad, he started drawing the strip ''t Moer' in 1995, which commented on the actual news in the city of Den Bosch. This strip has been collected in the book 'Ik Beloof Niks!', published by Silvester in 2002.