Alan Kupperberg attended the High School of Art and Design in New York City, graduating in 1971. He began illustrating and scripting for Marvel Comics in 1977, working on titles such as 'Amazing Spider-Man', 'Incredible Hulk', 'Iron Man', 'Savage Sword of Conan', 'Dr Strange', 'Thor', 'Captain America', 'Beavis and Butthead', 'Transformers' and many others. He had runs on teambook like 'The Invaders', 'The Avengers' and 'The Defenders', and also contributed to the 'What If?' title.
In 1978 he took over the 'Howard the Duck' weekly comic with Marv Wolfman, and also worked on the shortlived 'Incredible Hulk' newspaper strip. Kupperberg has also worked for Marvel Custom Comics, with clients such as Campbell's Soup, the U.S. Department of Energy, Sylvan Learning Center and The Dallas Times Herald. Kupperberg is responsible for the successful one-shot comic, 'Obnoxio the Clown vs. The X-Men', for which he did the writing, illustrating and lettering.
He eventually moved over the DC, where he had a run on the successful 'Justice League of America. He then worked on 'Warlord', 'The Fury of Firestorm', 'DC Comics Presents, 'Cops' and 'Dragonlace', and had a long run on 'The Blue Devil'. Kupperberg has done illustrations for Archie Comics, National Lampoon, Cracked Magazine, Spy and McClannahan Books. He worked on script development and character design for Sullivan Bluth Studios' 1990 animated feature 'Thumbelina'. From 1994, he worked with Nickelodeon/Viacom on the 'Tom Terrific' animated project. In addition to illustration, Kupperberg has done design work and scripting for numerous advertising and production agencies. His autobiographical strips have appeared in Comic Art and in the 'Streetwise' book.