Cartoonist and illustrator Neil O'Keeffe started out at the art department of the St. Louis Post-Dispatch in 1913. A year later, he moved on to the Chicago Tribune. In 1918 he moved to St. Paul, Minnesota, where he became a writer for the Daily News. His real cartoon career started in 1921, when he drew for Metropolitan Movies, as well as several pulp magazines. King Features hired him to replace Lyman Anderson on 'Inspector Wade' in July 1938. When 'Wade' was cancelled in 1941, O'Keeffe became a King Features staff artist. He also art on the comic adaptations of novels that King Features provided to newspapers in cooperation with the Book-of-the-Month Club.

Captain from Castil (novel by Samuel Shellabarger, Le Petit Journal, 14/4/1946)

From 1947 to 1956, Neil O'Keeffe was the author of 'Dick's Adventures in Dreamland'. This series was ordered by William Randolph Hearst himself. Hearst suggested at King Features that they should create a comic about American history and heroes. King Features assigned writer Max Trell and artist Neil O'Keeffe to the job, who let their main character "dream" his way through history. Neil O'Keeffe retired in the 1960s.