Ivo Pavone started drawing in 1943 and three years later, he was one of the collaborators of Uragano Comics, a prestigious group of authors that worked for Asso di Piche. In 1951, Pavone emigrated to Argentina and started to work for Cesare Civita, publisher of Editorial Abril. He worked for Oesterheld's Hora Cero and Frontera, illustrating the westerns 'Hueso Clavada' and 'Verdugo Ranch'. In South America, he recomposed most of the Asso di Piche team to create various comics, mostly westerns. Eventually, he took over the 'Sergeant Kirk' series from Hugo Pratt for two years, after which he went to work for Codex publishers.
In 1958, Pavone started working for Fleetway, making several comics for the English market. He contributed to the Cowboy Picture Library, and drew several war stories. He returned to Italy in 1962, where he took on numerous series, including 'Pecos Bill' and a large production for the French market, including 'Canada Jean' and 'Giddap Joe' for Mon Journal and 'Lupo Bianco', 'Rakar', 'Dick Demon', 'Les Cavernicoles', 'Jacky West - Bill et Barry', 'Havoc', 'Africanders', 'Galton et Trumbo' and 'Doc Sullivan' for Lug publishers. From 1975, he contributed comics to the Italian magazines LancioStory, Skorpio and Corrier Boy. Between 1979 and his retirement in 1983, he worked for Bonelli publishers.