Mark Payot was born in Antwerp, and he also attended the Academy of this Flemish city. He was one of the early artists working for the magazine Kleine Zondagsvriend, drawing the comic strip 'Tom Potter van de Geheime Dokken-politie' in cooperation with his brother Tom under the joint penname Pam in 1945 and 1946.
Starting in 1962, he worked with Belgian comedian Jef Cassiers on a comic strip starring Cassiers's character 'Het Manneke' for newspaper Het Laatste Nieuws and the magazine Kwik. He was mainly an illustrator and he also formed the literary cabaret De Koperen Haan. He was furthermore a set designer for the Belgian broadcasting company BRT, Nederlands Kamertoneel and K.V.S. In the 1970s he was head of publicity with a savings bank, while he continued to produce publications for the Antwerp city counsil.