Alfred J. Plastino began his career working for Youth Magazine at the age of 17. He later did work through comics studio Funnies, and assisted among others Bill Everett on 'Sub-Mariner'. During World War II, he spent most of his time at the graphic art office in the Pentagon, drawing war posters and doing illustrations for US Army magazines. Between 1944 and 1948, he worked on the sydicated 'Hap Hopper, Washington Correspondent' (later renamed to 'Barry Noble') strip, which he took over from Jack Sparling.
After the War, he went to work in a New York studio. After pencilling 'Captain America' for Marvel, he moved to National/DC Comics in 1948. There, he became one of the most prolific 'Superman' pencillers of the 1950s, together with Wayne Boring. Plastino was on the 'Superman' comic until 1968. He also illustrated numerous covers and spin-off titles, such as 'Superman's Girlfriend Lois Lane' and 'Superboy'. With Otto Binder, he created 'Supergirl' in 1959.
From 1966 to 1972 he was the artist on the 'Batman' daily. In 1973 he took over Henning Dahl-Mikkelsen's Ferd'nand strip and continued it until his retirement in 1989 (signing it with Al Mik). From 1982 to 1985, he was the artist for the Sunday 'Nancy' comic strip after Ernie Bushmiller passed away. Since his retirement he has worked with oil and water-colour painting.