Nicola Rosso was born in Turin, where he also studied at the Albertina Academy. He studied painting under Giácomo Grosso and Giovanni Reduzzi, and went to France for a couple of years afterwards. Rosso and his family moved to Brazil during World War II. There, he became art director of the Editora Brasilgráfica.
Shortly afterwards, he began working as an illustrator and comic artist. He drew comics in several genres, such as historical, juvenile, humor and war. His worked appeared in terror titles like Revista Terrir, Revista Estranho Mundo de Zé do Caixão, Revista Contos de Terror and Targo, as well as the humorous Era Xixo um Astronauta?. He also worked as a teacher at the Pan-American School of Arts. He had to give up his activities due to health reasons in 1976.