José Luis Salinas worked in the advertising field starting in 1929 for some of Argentina's biggest agencies. His earliest work appeared in El Tony and Paginas de Columba. Seven years later, he created his first sucessful comic series, 'Hernán el Corsario', which appeared in the pages of Patoruzu. This was soon followed by numerous series, like 'Capitàn Tormenta', 'La Costa de Marfil', 'Miguel Strogoff', 'Los Tres Mosqueteros', and others. For El Hogar, Salinas drew comic adaptations of popular literature.
In 1949, he moved to the United States, where he joined King Features. For this syndicate, he illustrated the newspaper strip of O'Henry's 'Cisco Kid' from 1951 to 1968. After 'Cisco Kid', Salinas focused on painting and illustration work, only returning to comics in 1971 to do the 'Gunner' strip with scripts by Alfreddo Grassi. His son, Alberto Salinas, also became a comic artist.