Wilfred Santiago started out doing some project for Milestone. The first pencil work he did was for 'Static', which was written by Ivan Velez. He also guest penciled some other titles like 'Icon' and 'Blood Syndicate'. For Marvel he did an issue of 'Cable' (#28 for writer Joseph Loeb), a 'Maverick' one-shot and a couple of others. He also co-wrote and drew a 120-page graphic novel called 'The Thorn Garden' for Eros Comix. Another book he did for Eros Comix was 'Pink'. 'Pop Life' is a comic series he did together with Ho Che Anderson, published by Fantagraphic Books in 1999. His first full-length book, 'In my Darkest Hour', was published by Fantagraphics in 2002.
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