Buford Tune was born in Texas and studied at the Chicago Academy of Fine Arts. In 1927, Tune headed for New York. He was hired his second day there by the art editor of the New York Post. After being loaned out to the Philadelphia Public Ledger, Tune returned to New York in 1928. He revived an old family comic strip called 'Doings of the Duffs', originally created by Walter Allman, and taken over by Ben Batsford.
At age 21, Tune was believed to be the youngest cartoonist in the country with a widely syndicated comic strip. When the 'Duffs' folded three years later, Tune received the assignment to paint giant balloons for the New York Thanksgiving Day Parade. In 1931, Tune returned to writing and drawing cartoons. Among others, Tune created 'Dotty Dripple', which ran for almost 30 years.