Manuel Vázquez made his professional debut in the mid-1940s in the magazine Flechas y Pelayos and its supplement Maravillas. In the late 1940s he moved to Barcelona, where he started his tenure at the publisher Bruguera, which lasted until 1986. He soon became one of the most popular artists of the periodical Pulgarcito with 'Las Hermanas Gilda', his first big series about two old ladies. Later on, he expanded his activities for this magazine and also for other magazines, with numerous series in various genres. All his characters were representative of the Spanish people, like 'La Familia Cebolleta', 'Angelito' and 'La Familia Gambérrez'.
Manuel Vázquez kept working for a large audience and became one of the main representatives of Spanish comics in the 1970s and 1980s. During this time, his work appeared in magazines such as El Papus, Makoki, Garibolo, Guai and Vińetas. He created several comics, including 'Don Cornelio Ladilla', 'El Sexo en la Prehistoria', 'Gu Gű!', 'Tita & Nic' and 'Cuentos del tio Vazquez'. For this last series, he himself was the main character. In 1990, he received the Grand Prize of the Salon del Comic de Barcelona for his entire oeuvre.