Hy Eisman started as a greeting card artist and quickly went to creating his own newspaper cartoon feature 'It Happened in New Jersey'. In the late 1950s he became an assistant to comic artists like Alfred Andriola ('Kerry Drake') and Vernon Greene ('Bringing up Father'). At the same time, he drew for comic books by Charlton (romance), ACG ('Adventures into the Unknown', 'Forbidden Worlds'), Marvel (romance), Harvey ('Blondie') and Western Publishing ('Nancy', 'Twilight Zone', 'Smokey Stover').
From 1967 to 1983 he illustrated the 'Little Iodine' series, which was originally created by Jimmy Hatlo. In 1986 he took over 'The Katzenjammer Kids', the world's oldest continuing comic strip. In 1994, Eisman added another comic legend to his repertoire when he started drawing the Sunday 'Popeye' strip. He is also is an instructor at the Joe Kubert School of Cartoon and Graphic Art in Dover, N.J. since 1976.
A panel from one of Eisman's romance comics inspired Roy Lichtenstein's painting 'Girl in Window' (1963).