Daniel Barry began his career working in the comic book field through George and Alan Mandel in 1941. Working through shops like Funnies Inc, Otto Binder's and Bernard Baily's studios, he worked on features for companies like Timely ('Scottie'), Feature Comics ('Black Owl'), Hillman ('Airboy', 'Boy King', 'Skywolf') and Fawcett ('Spy Smasher'). After a short interlude in the air force, Dan Barry continued his comic book career. He did freelance work for several magazines, and in 1947-48 he drew the 'Tarzan' daily strip. In the second half of the 1940s he also did the promotional 'Buster Brown' comic for Buster Brown Shoes, and various crime features for National/DC.
In 1951, Barry was asked by King Features Syndicate to revive the 'Flash Gordon' daily strip. Barry worked on the science-fiction strip until the 1990s, working with writers like Harry Harrison and Julian May, and being assisted over the years by artists like Bob Fujitani, Fred Kida and Frank Frazetta. In 1967 he also took on the 'Flash Gordon' Sunday page, following Mac Raboy's death. Barry left 'Flash Gordon' entirely in 1990, and began working as a writer/artist on 'Indiana Jones' comic books published by Dark Horse. He was the brother of 'Phantom' artist Sy Barry.