Carlos Botelho started his comic career coloring Cottinelli's 'Pirilau'-comics in ABC-Zinho. Later on, Carlos Botelho produced his own comics for ABC-Zinho, like 'Punchos de Bronze' and 'Les Aventuras do Zuncha, artista de Circo'. This last story is considered a masterpiece of early Portuguese comics, not only for its balanced use of word balloons, but also for its quick narrative style.
In 1928, Botelho's comics were published in the magazine Sempre Fixe. In this magazine, Carlos Botelho drew his satirical series 'Ecos da Semana'. This series was subjected to censorship several times, but still ran until 1950. Through stigmatizing the jobs of the Portuguese, Botelho portrayed a gallery of (anti)heroes like Pui, symbol of censorship, Parecemal and Dona Encrenca.
Although he was a very successful comic artist, Botelho is probably better known for his paintings.