Before beginning his artistic career, Bruno Brindisi was a scientist and a jazz player. He launched the Trumoon periodical in 1983, for which he created 'Ritorno al Nulla'. His professional career began in 1986, when two of his hobby projects were sold to the Leonetti studios, that published them in Boy Comics. From 1989 to 1991 he drew numerous stories for Acme. He then joined Bonelli, where he became a staff artist on 'Dylan Dog'. He also joined Mondadori's L'Intrepido, for which he did 'Billitteri'. Brindisi expanded his activities for Bonelli by taking on 'Nick Raider', while also doing 'Dylan Dog'.