Born in Brooklyn, New York, Sal Buscema is the younger brother of John Buscema. He started his career in the mid-1960s, inking his brother's work. He eventually became a successful penciller at Marvel as well for the next decades. Among his early Marvel work are 'The Avengers' and 'Sub-Mariner', and he is known for his work on 'Captain America', 'The Incredible Hulk', 'The Defenders', and several 'Spider-Man' titles between 1988 and 1996.
Buscema was also the inker of most of his own work from the 1970s. In the 1990s, he also inked for other artists again, including his brother's run on 'Fantastic Four'. He went into semi-retirement in the mid-1990s, but he did a run on 'Spider-Girl' with writer Tom DeFalco in the 2000s.