Gianni De Luca gave up his architecture studies to spend all his time on comics. He started in 1946 with his comic book 'Anac il Distruttore', followed in 1947 by 'Il Mago Da Vinci' for the weekly magazine Il Vittorioso. In the 1950s, De Luca started his collaboration with Il Giornalino, while in the following decade he almost stopped making comics to devote himself to illustration. He returned to comics in 1969 drawing the western comic 'Bob Jason'.
The following year, he started his most famous series, 'Il Commissario Spada', written by Gian Luigi Gonano. Among his following works, the most notable is a Shakespearean trilogy: 'La Tempesta', 'Amleto' and 'Romeo e Giulietta', realized from 1975 to 1978. In the 1980s, De Luca did such titles as 'Gian Burrasca', 'Paulus', 'Avventura sull'Onirico' and the biographies 'Marilyn Monroe' and 'Toto'. Gianni De Luca worked up to the end of his life: the story 'I Giorni Dell'Impero' was published posthumously.