Nicola Del Principe was a versatile comics artist, who has worked in various genres. He illustrated countless humerous and realistic comics for the publishing houses Alpe and Bianconi, but he also drew erotic comics. He was introduced to the comics world through the fiancé of his wife's sister, Enzo Chiomenti, a comics artist himself. At that time, Del Principe drew posters for the Christian Democratic Party, but he eventually settled in Milan to commence his career in comics.
He started out with the realistic 'Il Dominatore del West' at the publishing house Alpe in 1952 (text by Cesare Sovini). He then began a longtime collaboration with the publisher Renato Bianconi. For 40 years, he illustrated such series as 'Nonna Abelarda', 'Soldino', 'Trottolino', 'Papy', 'Birillo', 'Fiordipesco' and 'Luponario', but also 'Tom & Jerry' and 'Pinocchio'. In the late 1960s, he began drawing erotic comics, such as 'Angelica' and 'Il Camionista'. Del Principe was also present on the French and German markets, with such series as 'Erik il Vikingo', 'Tico Tigre', and 'Nicotina'.