Luca Dell'Uomo began his comics career at the Studio Origa in 1978, working for magazines like Corrier Boy, Monello, SuperGulp! and Blitz. For the magazine Adamo, he created the character 'Jonesco', and he took over the series 'Doctor Salomon', created by Civitelli. In the early 1980's, he went to work for the publications of Eura Editoriale. Dell'Uomo has illustrated some episodes of 'Dylan Dog' at Bonelli in 1986, before he joined the staff of 'Mister No'.