Bruno Duhamel attended the Comics atelier at the Faculty of Plastic Arts of the Saint-Charles art school in Paris, and also took courses in Fine Arts in Angoulême. He was a member of the Choco-Creed collecive and published his first work in the series Je suis pas petite!!! for La boîte à bulles. He then worked with Frédéric Brrémaud on two books in the series 'Kochka' (Paquet, 2003-04) and two in the series 'Harlem' (Vents d'Ouest, 2006-07).
He continued his collaboration with Brrémaud as a co-scriptwriter on the series 'Butch Cassidy', that was drawn by Jean-Emmanuel Vermot-Desroches. He served as the artist on Philippe Thirault and Thierry Lamy's Balzac adaptation 'Père Goriot' for Delcourt in 2009-2010. Duhamel is the artist of 'Les Brigades du Temps', a series written by Kris and published by Dupuis since 2012.