After graduating in Chemistry, Santiago Girón spent his time on comics, working as an amateur artist for fanzine Tarsus in the 1980s and a number of other fanzines in the 1990s. He worked on illustration and advertising to earn his living. He created the newspaper strip 'Vicente, el Vidente' for El Periódico de Ceuta. In 2000 he put out the graphic novel 'De Perros y Jabalíes'. He did scripts for short films, he designed theatrical sceneries and he went on contributing to fanzines like Androito Ke-Ke.
Santiago Girón provides the scripts for 'Tartessos', a series of publisher Almuzara which began in 2005. He undertook this ambitious project teaming up with Paco Nájera, who provides the art. The humorous stories take place in the year 550 BC. They are mainly located in the mythical city of Tartessos. He made 'Horizonte Azul' with Fran Carmona.