Raymond F. Houlihan attended the Art Students League, and worked as a comic book artist in the 1940s. Initially working through Funnies Inc., Houlihan illustrated features like 'Scotty of the Skyways', 'Steve Crawford' and 'The Undercover Man' for Centaur Comics. He did various features for Lev Gleason, Ziff-Davis and Ace Periodicals. He was an artist of filler comics for National/DC, including features like 'Hank the Yank' and 'Molly'. He additionally drew 'Tubby and Tack' for Timely and 'Little Leo' for Hillman.
In the second half of the 1940s, Houlihan did gag cartoons for American Magazine, Pic, Holiday and Argosy. In the 1950s he did illustrations for pulps and magazines including Saga, Sea Adventures and Reader's Digest. Houlihan then focused on painting, and has exhibited widely in both museums and historical institutions in the U.S., London and the Middle East.