Rex W. Lindsey attended the Joe Kubert School of Cartooning and Graphic Arts. He was part of comics studio The Kubies in the late 1970s. Through Joe Kubert, he did his first comic work in the early 1980s. He contributed to DC's 'Sergeant Rock' and Pacific's Vanguard Illustrated, Edge of Chaos and First Folio. He then got a job at Archie Publications, where he started out inking Archie's adventure line ('Blue Ribbon', 'Fly', 'Original Shield'), and eventually became one of the main artists for the Archie comics, including 'Archie and Friends', 'World of Archie', 'Archie 3000' and especially 'Jughead'.