While studying illustration at the College of Art in Dundee, Colin MacNeil drew his first pages for 2000 AD. Shortly afterwards, he was assigned to succeed Carlos Ezquerra as the artist of the 'Strontium Dog'. Later on, he also illustrated some 'Judge Dredd' stories.
MacNeil used a more painted style for his 'Chopper' strip and his 'Song of the Surfer', written by John Wagner, was an immediate success. The follow-up, 'America', knew an equal success. Colin MacNeil cooperated with his brother Roderick on 'Stripey' and illustrated 'The Road to Hell', written by Dwayne McDuffie and Matt Wayne.