Pat Masioni was born in Mikuzi, in the region Bas-Congo in 1961. He studied painting at the Academy of Fine Arts in Kinshasa. Since 1985, he collaborated with Publisher Saint Paul (or Médiaspaul). He drew several religious comics, and illustrated novels by writers Zamenga Batukezanga and Djungu Simna. He created comics for children, such as 'Maxou', and the thriller 'Le Fugitif'. He contributed to 'A L'Ombre du Baobab', a collection of comics by African artists about education and health in Africa, for which he created the story 'Niota'.
In 1990, four issues of Afro BD were published under the direction of Barly Baruti, by ACRIA (Atelier de la création, recherche et initiation à l'art), and featured artwork by Pat Masioni and other artists such as Kash, Makonga, N. Baruti and R. Kasuku (a Belgian whose real name is R. Henrard). He drew cartoons for the daily newspaper Le Palmarès and for Le GRI-GRI international, and he made the 'Samba Diallo' series for Planète Jeunes, a magazine for young Africans, read in 25 African countries. In 2005, he won international fame with the publication of a comic book in two parts on the war between the Hutu's and the Tutsi's in Rwanda in 1994: 'Descente en enfer' and 'Le camp de la vie', written by Grenier and Ralph. Masioni also created the comic album 'O Mon Pays', and is generally regarded as one of the most talented of a new generation of African comic artists.