Gonzalo Mayo was born in Piuira, Peru. He illustrated Ciro Alegría's comics adaptation of 'El Mundo es Ancho y Ajeno' in the weekly supplement Estampa de Expresso from 1963 to 1965. He made stories based on Peruvian literature, as well as the humour page 'Los Años Dorados'.
Mayo left Peru after the military coup of October 1968. In the USA, he drew several horror comics for magazines such as Eerie and Vampirella in the 1970s. In the 1990s he worked mainly as an inker at Vaillant comics, doing such series as 'Timewalker', 'Turok: Dinosaur Hunter', 'Harbinger' and 'Magnus Robot Fighter'.