Lincoln Peirce was born in Iowa. He studied art at Colby College in Maine, where he drew his first comic strip for the school newspaper. He also studied at the Skowhegan School of Painting and Sculpture, after which he was an art teacher with the Xavier High School in New York City. He moved to Maine in 1992, where he began his career as a writer.
He created the comic strip 'Big Nate', which has been syndicated to over 300 newspapers since 1991. Bearing striking resemblances to 'Calvin & Hobbes' by Bill Watterson, the strip is about a small boy and his great ambitions. Peirce has also used the character in a series of novels, and a popular 'Big Nate Island' was added to the virtual world Poptropica.com. Peirce also hosts a local radio show devoted to honky tonk and western music.