Luigi Piccatto cancelled his medicine studies to start a career in comics. He got his first job at the editorial team of Corrier Boy. In the early 1980s, he drew comics for Lanciostory and Skorpio. At the same time, he was a freelance advertising artist. He is part of the 'Dylan Dog' staff from 1986. He also worked on other Bonelli series, such as 'Magico Vento'.