Michel Pichon is the son of a writer (father) and a comedian (mother). He studied applied arts in Paris for four years. He has been active in the illustration and comics field since 1966. His work has been published in such magazines as Hara-Kiri, Lui, Plexus, Le Mirroir Fantastique, Penthouse and Playboy. He is one of the regular contributors to the comic magazines Fluide Glacial and Psikopat. His work has been collected in albums such as 'A Toi pour la Vie', 'Je Reviens, Je Vais Faire les Courses', 'La Vie Exemplaire de Mme. La Pute' and 'La Vie des Pauvres'.
He was one of several artists to make a graphic contribution to 'Pepperland’ (1980), a collective comic book tribute to the store Pepperland, to celebrate its 10th anniversary at the time. He also contributed to another official collective homage 'Rocky Luke' (Goupil, 1983), paying tribute to Morris' 'Lucky Luke'. In 1990, he paid graphic tribute to François Walthéry in the collective homage book 'Natacha. Special 20 Ans' (Marsu Productions, 1990), which celebrated the 20th anniversary of Walthéry's series 'Natacha'.