Ana Pili attended the Garaycochea School of Art. She has worked as a primary school and music teacher until the 1990s. She began her work as an artist with the Ministry of Education in Argentina, and with magazines like Le Chisté. She subsequently made illustrations and comics strips for publishers like Atlántida, Alfaguara and Santillana.
Newspaper La Prensa ran her comic strip 'Capuchita' and for 17 years she made game and editorial pages like 'Juegos del Verano', 'Los 100 Juegos', 'El gran libro de juegos de Clarín', 'Ocio' and 'Juegos de Altura' for daily newspaper Clarín.
Furthermore, Pili has done commercial comics and other artwork for companies like Competir, Accenture, Telefónica and Office Gym, that have been published in Argentina, Chile, Mexico and Kuwait.
Pili's work is distributed throughout Europe through Hachel's agency since 2005.