Stefano Raffaele was born in Milan and made his professional comics debut with drawing the series 'Lazarus Ledd' from scripts by Ade Capone for Star Comics. Also with Capone, he made the mini-series 'Il potere e la gloria', the first Italian superhero comic. In 1995, Stefano Raffaele started working for the American market. His first work was for Valiant titles like 'Eternal Warrior' and the 'X-O Manowar Yearbook'. He then began an association with DC Comics, drawing 'Underworld Unleashed/Dark Uprising' and several issues of 'New Gods'. For the same publisher he later contributed to 'Bat-Man/Shadow Of The Bat' and 'Birds of Prey'.
Conan and the Scarlett Sword #1
De Raffaele was additionally present at Marvel with issues of 'X-Factor' and the mini-series 'Conan Vs The Lord Of The Spiders' and 'Conan And The Scarlett Sword' with Roy Thomas. By 1999 he dropped his activities for the US market and created 'Arkhain' with Lorenzo Calza for the Cult Comics label of Marvel Italia.
He set up his Quantumdream studios in 2001 and created his first solo project, 'Fragile', for Les Humanoïdes Associés in France in 2003. He participated in the anthology series 'Hellboy-Histoires bizarres' for the publishing house Delcourt.
In 2007 he teamed up with Christophe Bec to create the horror series 'Pandemonium', based on the Waverly Hills Sanatorium legend, also for Les Humanoïdes. Also with Bec, he created 'Sarah' for Dupuis in 2008 and 'Under' for Le Lombard in 2010. His one shot 'Loving Dead' was published by Les Humanoïdes in 2009. In the following year he also drew the second volume of the series 'Caravan' from a script by Michele Medda at Clair de Lune.