Mathieu Reynès was born near Paris, but he spent most of his childhood near the Basque coast. He initially pursued a scientific education, but eventually turned to 3D animation at the CNBDI in Angoulême. He has been working fulltime as a comic artist since the early 2000s, mostly in cooperation with scriptwriter Frédéric Brrémaud. After creating their first albums for Paquet ('Banana Fight', 2002) and Soleil ('Sexy Gun', two books in 2003-2004) they began an association with Éditions Bamboo.
They created the series 'Lola Bogota' in 2005 and 2006 and co-wrote the scripts for a variety of humor books, such as 'Les Tennismen' (art by Bertolucci), 'Les Informaticiens' (art by Toulon), 'Toutou & Cie' (art by Emmanuele Soffritti) and 'Les Maîtres Nageurs' (art by Reynès himself). Reynès additionally created the series 'Alter Ego' with Denis Lapière and Pierre-Paul Renders for Dupuis in 2011 and wrote the script for 'La Mémoire de l'eau' for Valérie Vernay in 2012.