Born in Chioggia, Luca Salvagno graduated from the Venice Academy of Fine Arts. He began his career working for Messaggero dei Ragazzi in the 1980s. He became a member of the Jacovitti Club in the 1990s and participated in the club's magazine. His work was noted by Jacovitti, who asked him to become his assistant. Salvagno cooperated on the artwork and coloring, and eventually took over 'Cocco Bill' in Il Giornalino after Jacovitti's death in 1997.
Salvagno has also worked as a children's book illustrator, and he also illustrated the updated versions of 'Storia d'Italia a fumetti' and 'Storia del Mondo a fumetti' of the publishing house Mondadori. Luca Salvagno is currently a lecturer with the Pietro Selvatico Art Institute in Padova.