Patrick van Lierde studied at the Berchem Academy, after which he headed for Brussels. In 1968, he worked at the Belvision animation studios. A year later, he joined the Vandersteen studios, where he was assigned to work on the 'Bessy' stories for the German market under guidance of Karel Verschuere. He inked a lot of the 'Bessy' stories pencilled by Jeff Broeckx, including the 1980s series 'Bessy Natuurcommando', written by Marck Meul.
Van Lierde did the pencilling of the 23rd album in this series, 'De Mijn', himself. For Suske en Wiske holiday specials, Van Lierde created stories with the model 'Iris', in cooperation with Marck Meul and Ronald Grossey. In the 1990s he worked with Jef Nys on 'Jommeke'. He was also a teacher at two Antwerp art academies, and a painter.