Brian Bram was born in Chicago in 1955. Bram discovered underground comics, and began a prolific period of drawing for personal pleasure and for publication. His first paid work was a logo for Bunion Stew, a local band. He began contributing to Triad, a Chicago-based alternative magazine that published work by Skip Williamson and others. At eighteen Bram served briefly as Art Director for Triad. Bram attended the Cleveland Institute of Art beginning in 1975. Underground cartoonist Jay Lynch, a friend of Bram's, introduced him to Cleveland's Harvey Pekar who hired him to illustrate stories in 'American Splendor', a comic book Pekar was writing. Bram contributed to the first two issues of this title.
Bram moved to Rochester, New York in 1980 and opened The Effects Factory, a film animation and special effects studio. He also produced and hosted a live all night program on a local television station. In 1985 Bram created the Computer Graphics department at CGI, a state-of-the-art video post-production facility. In 1987 Bram moved to Boston, where he continued his computer design work as Design Director at Editel.In 1993, Bram founded one of the world's first Interactive Agencies.