Guido Buzzelli, the son of a painter, made his artistic debut at the age of nineteen, when his first caricatures were published in the newspaper Argentovivo. During the next ten years, he worked in comics, specializing in making cover illustrations for publications such as 'Raff Poigno d'Acciaco' and adventure series like 'Flash Gordon' and 'The Phantom'.
In 1954, he moved to England, where he created the comic 'Angélique' for the Daily Mirror. Back in Italy, he devoted himself to painting for a while, but at the end of the 1960s he returned to the comics field with a more personal production, 'La Rivolta dei Racchi'. After this story was translated into French, it was published in Charlie Mensuel, which also published Buzzelli's 'Les Labyrinthes', 'Zil Zebub', 'H.P.' and many more.
Guido Buzzelli was given an award by the international Salon de Luca in 1973, the same year he created the western 'Nevada Hill' together with writer Jean-Pierre Gourmelen. Using the pseudonym Blotz, he made a number of erotic illustrations which appeared in Charlie Mensuel and the collections 'Démons' and 'Buzzelliades'. Guido Buzzelli's work was published in several French magazines throughout the 1970s.
He was one of several artists to make a graphic contribution to ‘Pepperland’ (1980), a collective comic book tribute to the store Pepperland, to celebrate its 10th anniversary at the time.
In 1976, working with writer Gino d'Antonio, he made 'l'Homme de Bengale', and in 1981, he contributed to the series 'L'Histoire du Far West en Bandes Dessinées', edited by Larousse. In 1985, Buzzelli's 'Zasafir' appeared and he took up the famous western by Bonelli, 'Tex Willer'. Guido Buzzelli died in 1992, after a very productive and diversified career in comics.