Pasquale Del Vecchio graduated in Architecture from the Polytechnic Institute of Milan. He made his first steps in the field of comics while still a student, with some contributions to the review 1984. He subsequently collaborated with Il Giornalino and Corriere dei Piccoli, most notably with a comics adaptation of the African trips of famous explorer and mountaineer Walter Bonatti.
By 1991 he began his collaboration with the publishing house of Sergio Bonelli. His first work was an album of 'Zona X', and this was followed by installments in the series 'Nick Raider' and 'Napoléon' throughout the 1990s. Since 2005 he is also a staff artist for the famous Italian cowboy 'Tex'.
In 2003 he had also joined Les Humanoïdes Associés in France. Together with Richard D. Nolane, he developed 'Russel Chase', a series based on cryptozoology and its mysteries. Three books were published until 2007, after which Del Vecchio continued to work for French-Belgian publishers.
With Federico Bini he made 'Mary Diane' for Clair de Lune (2009), and he joined Le Lombard for the creation of 'Blackline' with Hervé Loiselet and Laurent Queyssi (2011-2012). He was present at Glénat with 'Les Montefiore' in cooperation with Christophe Bec and Stéphane Betbeder and at Dargaud with the fifth album in the series 'W.W. 2.2' in cooperation with Luca Blengino (2013).
Del Vecchio has been a teacher at the School of Comics in Milan, and at the local School of Applied Arts. He has now abandoned his teaching activities to focus solely on his work as a comic artist.