Didier Eberoni started working in the illustration field in 1976 after studying Applied Arts for a year and a half. He published his first black and white comics in magazines like Rock and Folk and Pilote, and in cooperation with scenario writers such as Philippe Druillet and Jacques Lob. In 1979 he joined Métal Hurlant where he teamed up with Rodolphe and created 'Le Centaure Mécanique'. The realisation of this story lasted two and a half years, and an album in direct colors was published by Les Humanoïdes Associés in 1982.
In the same period, Eberoni did several cover illustrations for publishers like Seghers, Néo and Temps Futurs. In the 1983, he made 'Carcasses' with Frada in Métal Hurlant. Two years later, in the same magazine, he produced 'John and Betty'. Afterwards, Eberoni left the comics field and focused on painting and his illustration work. In 1996, he made 'Teknikolor', an illustrated album for children, published by Le Seuil. In 2001, he teamed up with novelist Patrick Raynal and made 'Sexual Killer' for L'Écho des Savanes.