After Charles Flanders graduated from high school, he got a job in the art department of a silkscreen company in Buffalo, at the same time attending classes at the Allbright Art School. In 1928, he moved to New York, where he eventually was employed by King Features Syndicate in 1932.
He worked on several comics by other artists, varying from 'Tim Tyler's Luck' to 'Bringing Up Father'. In 1935, he made the only strip he ever created by himself: 'Robin Hood', which appeared as a Sunday feature. It ran for only three months.
Not defeated by this, Flanders went on doing comics that were created by others. He took over 'Secret Agent X-9' from Alex Raymond, which he continued until 1938. In addition, he continued the 'King of the Royal Mounted' Sunday page from 1936. He became the sole artist on this strip in 1938.
A year later, he was assigned to Fran Striker's 'The Lone Ranger', which he drew until 1971. After his retirement, Charles Flanders settled in Spain, where he died in 1973.