Nicola Genzianella attended courses at the Milan Comics School. After his graduation in 1989, he started working for advertising agencies. He began a collaboration with the magazine L'Intrepido in 1994 and created series like 'Crononauti' and 'No Exit' with Giorgio Schottler. In 1997 he started adapting famous 19th Century literary works for the publishing house Xenia. At the same publisher, he also illustrated 'Demon Hunter'.
He has worked for the Catholic publishing house San Paulo, and for the magazine Il Giornalino. He is a regular artist on the vampire series 'Dampyr' for the publishing house Bonelli since 2000. In 2008 he took over the artwork of the French comic series 'Bunker' from Christophe Bec, who continued to do the scripts together with Stéphane Betbeder.